■ Sponsored Session:
Title: From Discovery to Impact: Translating Noster’s R&D into Real-World Healthcare Solutions
Speaker: Adarsh Sandhu,
Board of Directors, Chief Scientific Officer (CSO), R&D Division, Noster Inc.
Adarsh Sandhu, Chief Scientific Officer at Noster Inc., delivered a compelling talk titled “From Discovery to Impact: Translating Noster’s R&D into Real-World Healthcare Solutions.” In his presentation, Sandhu emphasized the indispensable role of interdisciplinary collaboration in translating fundamental scientific discoveries into tangible healthcare applications.
Introducing the concept of the microbiome, he explained how gut microbiota—microorganisms residing in the human digestive tract—play a crucial role in health by metabolizing dietary components into bioactive compounds known as metabolites. He described the gut as a dynamic microfactory, where these microbial processes generate metabolites with profound physiological effects.
Sandhu highlighted Noster’s core mission: to understand the functional roles of gut bacteria and their metabolites, and to harness this knowledge to guide dietary interventions and therapeutic innovations. He underscored the growing body of research linking gut health not only to metabolic disorders such as diabetes but also to neurodegenerative diseases like Parkinson’s.
A particular focus of his talk was Noster’s pioneering work on postbiotics—metabolites produced by beneficial bacteria. He detailed the company’s innovation in biomanufacturing HYA, a key metabolite derived from natural oils, with potential applications in both pharmaceuticals and functional foods. This breakthrough has led to the development of HYA-50F, a functional food product now entering the market.
Sandhu elaborated on the biotransformation process, where selected bacterial strains and enzymes convert oils into therapeutically relevant metabolites. These compounds, he noted, show promise in modulating hormone production to treat metabolic diseases.
He also acknowledged the critical support of research institutions such as Kyoto University and Keio University, and government agencies including the New Energy and Industrial Technology Development Organization (NEDO), in advancing Noster’s R&D efforts.
Beyond product development, Dr. Sandhu spotlighted Noster’s commitment to fostering global scientific collaboration. He introduced the Noster and Science Microbiome Prize, an international award recognizing outstanding young researchers in the microbiome field. He shared examples of ongoing partnerships with scientists across the United States and United Kingdom, including projects addressing gastrointestinal challenges in premature infants.
In closing, Sandhu reflected on the increasingly interdisciplinary nature of microbiome research, now enriched by contributions from physicists, mathematicians, and artificial intelligence experts. He extended an open invitation to professionals across fields to contribute to Noster’s mission. His presentation underscored the transformative potential of microbiome science and the vital importance of collaboration in shaping the future of healthcare.
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